Not in a large scale between the big powers, but I don't think the detonation of a small scale weapon on the border between India and Pakistan is entirely out of the question. Perhaps as an over eager deterrent or as an reckless escalation by a battlefield commander. Not likely, but not so unlikely as to be entirely comfortable.
It may all be bluster on both sides, but those countries are nuclear powers engaged in a cold-to-occasionally-tepid war that in many ways mirrors the East/West stand off of the 20the century. You couldn't rule anything out.